Barcelona are within sight of progress from Group B as they travel to take on second-placed Internazionale.
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The emphatic home win against Crvena zvezda took Liverpool top of Group C and last season's runners-up seek a repeat in Serbia.
Napoli were denied three points at Paris Saint-Germain by a late Ángel Di María goal as the teams renew acquaintance.
After a record-equalling defeat on matchday three, Atlético Madrid are out to turn the tables on Borussia Dortmund in Spain.
Tottenham's draw at PSV Eindhoven last time out did little for either side's Group B hopes with a first win now imperative.
Despite the matchday three draw that gave both a first Group A point, time is ebbing away for Monaco and Club Brugge.
Schalke and Galatasaray were unable to find a goal in Turkey and will hope for a breakthrough in Gelsenkirchen.
Having established themselves as Group D leaders with victory at Lokomotiv Moskva, Porto want more of the same in the home game.
Barcelona downed Real Madrid 5-1 and Paris saw off Marseille 2-0, after wins for the likes of Juventus and Liverpool.
Barcelona downed Real Madrid 5-1 and Paris saw off Marseille 2-0, after wins for the likes of Juventus and Liverpool.
Barcelona downed Real Madrid 5-1 in the Clásico after Bayern, Juventus, Liverpool and Atlético all triumphed.
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