Liverpool will climb above Chelsea and into second place in the Premier League table if they can avoid defeat at home to Brentford - but they must do with without Mo Salah and Saido Mane.
Romelu Lukaku and Jack Grealish might have been the most expensive players on show, but Kevin De Bruyne scored the goal that puts Man City all but out of Chelsea's reach in the title race.
Philippe Coutinho marks his return to the Premier League with a seat on the bench, while Lucas Digne makes his Aston Villa debut as Manchester United visit Villa Park.
Manchester City take on Chelsea at the Etihad knowing victory will further extend their lead at the top of the Premier League. The visitors must win to retain any hope of a title challenge.