Third meets second in the Premier League as London rivals clash at Stamford Bridge. Christian Pulisic is a Chelsea substitute, while Joe Rodon makes his first league start for Tottenham.
With Paul Pogba still out, Donny van de Beek makes his first Premier League start as Manchester United take on fifth-placed Southampton. Follow LIVE with ESPN!
Liverpool can open up a three-point gap at the top of the table with a win at the Amex Stadium, where Sadio Mane starts among the substitutes. Follow LIVE with ESPN!