If Ronaldo can help Juve past Lyon, he faces a quarterfinal vs. Man City or former club Real Madrid and that might be the end of the line. Bayern Munich are the favourites now.
The Champions League will be formed of one-off matches in Lisbon in August, but a draw for the quarterfinals and semifinals needs to be made first at 11 a.m. BST/ 6 ET.
With a win at relegation-threatened Villa, United will go within one point of the top four. Ole Gunnar Solskjaer selects an unchanged line-up for the fourth straight Premier League game.