Barcelona hold a narrow advantage at the halfway point of the tie after victory at Old Trafford.
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Liverpool have one foot in the UEFA Champions League semi-finals after a 2-0 win against Porto.
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Manchester United need to turn around their fortunes against Barcelona as they welcome them for Wednesday's first leg.
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The 1996 final is replayed in Amsterdam on Wednesday as Ajax welcome Juventus for their first leg.
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"We can show everyone that we are just as good as them, or even better," the midfielder Frenkie de Jong tells UEFA.com.
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As he prepares for his first game at Old Trafford, Sergio Busquets recalls his two final encounters with the Red Devils.
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The Scout has plenty to ponder as the quarter-finals kick off, with a number of big hitters making the 15-man squad.
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The Fantasy transfer deadline is 21:00CET on Tuesday; our experts predict the line-ups for the first legs.
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Full details as Tottenham welcome Manchester City to their new stadium for an all-English quarter-final.
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Premier League leaders Liverpool welcome suspension-hit Porto for Tuesday's quarter-final first leg.
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"I'm trying to give everything I've got so I can lift the trophy one day," says Liverpool's Senegalese forward.
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"If it's not this year, I think it will be next year," said Riyad Mahrez as he yearns for his first UEFA Champions League winners' medal.
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Barcelona meeting Manchester United in Europe means another entry into their string of classic ties.
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Which players can you ill afford to miss out on, and are there still any bargain buys others aren't aware of?
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The #UCLfantasy transfer deadline is 21CET on Tuesday; UEFA.com predicts the line-ups for this week's first legs.
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