Manchester United and Borussia Dortmund have difficult tasks in the second legs, but they can take hope.
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There have only been eight trebles of league, domestic cup and UEFA Champions League. Could we have a ninth this season?
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Five-time winner Paolo Maldini is the latest UEFA Champions League centurion under the spotlight.
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A late first-leg turnaround has put Manchester City in pole position and leaves Schalke facing a fourth successive last-16 elimination.
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Juventus have it all to do as Atlético Madrid come to Turin, two late first-leg goals having given the Spanish side the upper hand.
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The first installment of the heavyweight contest between Bayern München and Liverpool failed to produce a goal as the tie concludes in Germany.
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No goals in France mean Barcelona and Lyon both remain unbeaten this season, so something has to give at the Camp Nou.
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We look at which team has gone through historically following the same first-leg results as this season's round of 16.
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Can Manchester United do something unprecedented? We look at each team's chances of going through.
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