Liverpool had to settled for a share of the spoils on the south coast as Pascal Gross scored a stoppage-time, VAR-assisted penalty.
Liverpool were denied victory by VAR as Andrew Robertson was penalised late on to allow Brighton and Hove Albion to rescue a 1-1 Premier League draw at the AMEX Stadium.
Diogo Jota's ninth Liverpool goal looked set to prove enough for the Reds to move three points clear of Tottenham at the top of the table, but the Reds' work was undone in stoppage time.
Robertson swung out a foot and clipped Danny Welbeck and, though referee Stuart Attwell spotted no infringement, he changed his decision once he checked the pitch-side monitor.
Unlike Neal Maupay, who drilled wide from 12 yards to let Liverpool off the hook in the first half, Pascal Gross made no mistake.
It was a third VAR call of the game that went against Liverpool, with Mohamed Salah and Sadio Mane having goals rightly ruled out for offside as Jurgen Klopp was left to rue the technology once more.