The Cottagers have won just one of their last 14 Premier League matches against Spurs (D3 L10), winning 1-0 at White Hart Lane in March 2013 under former Tottenham manager Martin Jol.
Alli starts for the first time since the opening day of the season as Jose Mourinho also makes three alterations. The other changes see both full-backs, Serge Aurier and Reguillon, drop out for Doherty and Davies. After an impressive performance against Burnley, it comes as no surprise that Bale once again starts.
Scott Parker has no fresh injury problems but opts for three changes from last game. Robinson replaces Tete at full-back, Lemina comes in for Zambo Anguissa to partner Reed and Cavaleiro is preferred ahead of De Cordova-Reid.
SUBS: Harry Winks, Sergio Reguillon, Erik Lamela, Lucas Moura, Japhet Tanganga, Moussa Sissoko, Carlos Vinicius, Joe Hart, Eric Dier.
TOTTENHAM (4-2-3-1): Hugo Lloris; Matt Doherty, Davinson Sanchez, Toby Alderweireld, Ben Davies; Pierre-Emilie Hojbjerg, Tanguy Ndombele; Dele Alli, Gareth Bale, Son Heung-Min; Harry Kane.
SUBS: Andre-Frank Zambo Anguissa, Terence Kongolo, Tim Ream, Kenny Tete, Joe Byran, Fabri, Josh Onomah, Bobby De Cordova-Reid, Aleksandar Mitrovic.
FULHAM (4-2-3-1): Alphonse Areola; Ola Aina, Tosin Adarabioyo, Joachim Andersen, Antonee Robinson; Mario Lemina, Harrison Reed; Ademola Lookman, Ivan Cavaleiro, Ruben Loftus-Cheek; Josh Maja.
The Cottagers remain on the tail of 17th-placed Newcastle United, three points behind safety as it stands. Most recently the hosts were held to a goalless draw with Crystal Palace. The visitors sit in eighth, six points away from the Champions League spots and crushed Burnley 4-0 last time out.
Hello and welcome to live coverage of the Premier League fixture between Fulham and Tottenham.