Real Madrid's sole Group G defeat came at CSKA Moskva, who are hoping to take third place on matchday six.
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Ajax and Bayern are both in the last 16 with a game to spare, with first place in Group E to be settled in Amsterdam.
Valencia and Manchester United have shared six draws in their nine previous meetings as they meet at Mestalla.
Young Boys have one last chance to get their first Group H win – a tall order against section leaders Juventus.
A point is all Manchester City need to win Group F, while Hoffenheim aim to end their debut campaign in memorable fashion.
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Shakhtar Donetsk and Lyon both have Group F's second qualification berth in their sights in Ukraine.
Benfica will be looking to finish Group E positively while AEK Athens are out to avoid a clean sweep of defeats.
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Viktoria Plzeň are playing for third place, and UEFA Europa League football, against Group G runners-up Roma.
Liverpool and Napoli face a matchday six showdown, the Italian side travelling to Anfield with the upper hand in Group C.
Barcelona have already won Group B, with final opponents Tottenham hoping to join them in the round of 16.
Monaco are hoping to end a long winless run as they bow out against Dortmund, the last side they beat in Europe.
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Atlético Madrid will seek to secure first place in Group A away to Club Brugge, who are sure to finish third.
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Porto will finish first in Group D regardless of the result in Istanbul, with Galatasaray chasing third place.
Paris will reach the knockout rounds with victory away to Crvena zvezda, who have their sights set on the UEFA Europa League.
