Who's likely to start, who might be left out and who is unavailable? UEFA.com predicts all the line-ups.
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There is all still to play for on matchday five, meaning a host of leading names in contention for the captain's armband.
Barcelona equalised late against Atlético to stay top as Paris remained perfect Juve, Manchester City and Dortmund marched on.
Real Madrid lost 3-0 at Eibar on Saturday while Jason Denayer was the unlikely hero for Lyon on Friday evening.
Ahead of matchday five, UEFA.com crunches the numbers to find out which players are predicted for big points hauls.
Jason Denayer was the unlikely hero for Lyon on Friday evening but there was frustration for Galatasaray and Club Brugge.
UEFA.com looks at which players impressed in the international break as the search for matchday five pointers starts.
Céléstine Babayaro was 16 years and 87 days old when he made his #UCL debut on 23 November 1994; meet the competition's ultimate wonderkids.
UEFA Champions League matchday five promises more high-stakes drama across the continent – who will steal the show?
On 22 November 2016, Dortmund and Legia Warszawa shared 12 goals in a group stage match; can you remember the final score?
