Inter are already lagging behind in Group F and can ill afford to lose more ground when Borussia Dortmund visit Milan.
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Ajax are setting the pace in Group H, although Chelsea's visit could stir some painful memories of English opposition.
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Liverpool are looking to end a four-match run of away defeats in the group stage, although Genk are no pushovers at home.
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LOSC have lost their first two Group H games and now face a Valencia side they have never beaten in four attempts.
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Leipzig lost at home last time out and will be keen to avoid a repeat as Group G leaders Zenit visit again.
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Benfica are bottom of Group G and are in urgent need of a win as Lyon, who are four points better off, visit Lisbon.
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Salzburg have shown fine form in front of goal on their group return, and now have the opportunity to turn the tables on Napoli.
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Having picked up a single point apiece from their first two matches, Galatasaray and Real Madrid need a Group A victory.
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Juventus will attempt to continue their fine record against Russian sides when Group D rivals Lokomotiv Moskva come to Turin.
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Atlético Madrid are well placed in a tight Group D and will be aiming to inflict a third defeat on bottom side Bayer Leverkusen.
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Manchester City have cruised through Group C to date and now take on an Atalanta side who have lost both games.
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Fresh from a seven-goal display on Matchday 2, Bayern are looking to further strengthen their Group B position at Olympiacos.
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Tottenham shipped seven goals at home for the first time on Matchday 2 and now take on a buoyant Crvena zvezda.
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Club Brugge's six-match unbeaten run in the UEFA Champions League will be under the microscope as Group A leaders Paris visit.
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Shakhtar and Dinamo both have three points from their first two Group C games as they meet at Kharkiv's OSK Metalist Stadion.
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Six forwards scored for the second game in a row on matchday two, including excellent budget signing Erling Braut Haaland.
Six forwards scored for the second game in a row on Matchday 2, including excellent budget signing Erling Braut Haaland.
Serge Gnabry's 22-point haul is unlikely to be better this season, while substitutes made a sizeable impact.
Serge Gnabry's 22-point haul is unlikely to be better this season, while substitutes made a sizeable impact.
Ball recoveries have changed the complexion of the game for defenders, with Virgil van Dijk among the matchday 2 beneficaries.
