UEFA.com delves into the numbers and finds clean sheets were at a premium in the first legs.
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Erling Braut Haaland and Robert Lewandowski continued to hit the net, although injury means the latter is likely to miss the second leg.
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Key differentials were once again to the fore in the round of 16 first legs, although Serge Gnabry took the headlines again.
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A first-leg comeback has put Manchester City in the driving seat as Real Madrid travel to north-west England facing a 2-1 deficit.
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Antoine Griezmann's first-leg away goal has given Barcelona an advantage after the game in Naples finished 1-1.
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Led by Serge Gnabry's first-leg double, Bayern München have one foot in the quarter-finals as Chelsea come to Germany.
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Lucas Tousart's first-leg goal gave Lyon a first win against Juventus, who once against face a round of 16 deficit on home soil.
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Valencia will need to must a remarkable home recovery to turn round their tie against Atalanta after a 4-1 first-leg defeat.
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An early Saúl Ñíguez goal in Madrid means holders Liverpool once again face a second-leg deficit against Spanish visitors.
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Timo Werner's penalty has given Leipzig a narrow advantage, although Spurs have history when it comes to turning round a 1-0 home defeat.
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Two Erling Braut Haaland strikes have given Dortmund an advantage to take to Paris, although Neymar's away goal could prove crucial.
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Ahead of Matchday 7, UEFA.com looks at some obvious selections and some lesser-owned options.
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