Lyon have lost six of the last seven round of 16 ties and now take on a Juventus side they have never beaten.
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Liverpool return to the scene of last season's final triumph to take on an Atlético Madrid side with a formidable home European record.
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Borussia Dortmund meet former coach Thomas Tuchel, whose Paris Saint-Germain side have suffered three last-16 exits in a row.
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Kylian Mbappé, still only 21, is by far the most prolific UEFA Champions League scorer of his age.
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Ciro Immobile hit a hat-trick against Sampdoria to move six points ahead of Robert Lewandowski and Timo Werner.
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Check here for the UEFA Champions League round of 16 teams' January signings.
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St-Pierroise from Reunion are in the French Cup round of 32; reach Europe and they could break records.
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The UEFA.com fans' Team of the Year 2019 includes seven players making their first appearance.
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Barcelona head into the last 16 aiming to extend a sequence of 35 home games without loss.
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Barcelona head into the last 16 aiming to extend an unprecedented streak of 35 home matches undefeated. UEFA.com pores over all the competition's milestones.
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Ciro Immobile has moved a goal ahead of Robert Lewandowski at the summit, with Timo Werner another goal behind.
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Cristiano Ronaldo, Lionel Messi and Sergio Ramos are all climbing the leaderboard.
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Who is in Cristiano Ronaldo's sights? How far ahead is Lionel Messi? Meet the round of 16 teams' top marksmen
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Yet to lose after 20 games, will Liverpool be the 34th side to end a 21st-century European top division unbeaten?
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Yet to lose after 20 games, will Liverpool be the 34th side to end a 21st-century European top division unbeaten?
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Liverpool look to be striding toward title glory in England, but bad things happen – as UEFA.com discovers.
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