For the third match running Slavia Praha face a former European champion as Barcelona come to the Czech Republic.
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Inter are already lagging behind in Group F and can ill afford to lose more ground when Borussia Dortmund visit Milan.
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Ajax are setting the pace in Group H, although Chelsea's visit could stir some painful memories of English opposition.
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Salzburg have shown fine form in front of goal on their group return, and now have the opportunity to turn the tables on Napoli.
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Benfica are bottom of Group G and are in urgent need of a win as Lyon, who are four points better off, visit Lisbon.
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LOSC have lost their first two Group H games and now face a Valencia side they have never beaten in four attempts.
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Leipzig lost at home last time out and will be keen to avoid a repeat as Group G leaders Zenit visit again.
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Having picked up a single point apiece from their first two matches, Galatasaray and Real Madrid need a Group A victory.
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Manchester City have cruised through Group C to date and now take on an Atalanta side who have lost both games.
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Tottenham shipped seven goals at home for the first time on Matchday 2 and now take on a buoyant Crvena zvezda.
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Club Brugge's six-match unbeaten run in the UEFA Champions League will be under the microscope as Group A leaders Paris visit.
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Shakhtar and Dinamo both have three points from their first two Group C games as they meet at Kharkiv's OSK Metalist Stadion.
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Juventus will attempt to continue their fine record against Russian sides when Group D rivals Lokomotiv Moskva come to Turin.
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Atlético Madrid are well placed in a tight Group D and will be aiming to inflict a third defeat on bottom side Bayer Leverkusen.
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Fresh from a seven-goal display on Matchday 2, Bayern are looking to further strengthen their Group B position at Olympiacos.
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With the group stage starting to take shape, premium goalkeepers are already proving to be value for money.
321 Hits
Ball recoveries have changed the complexion of the game for defenders, with Virgil van Dijk among the Matchday 2 beneficaries.
233 Hits
Six forwards scored for the second game in a row on Matchday 2, including excellent budget signing Erling Braut Haaland.
336 Hits
Serge Gnabry's 22-point haul is unlikely to be better this season, while substitutes made a sizeable impact.
234 Hits
Ball recoveries have changed the complexion of the game for defenders, with Virgil van Dijk among the matchday 2 beneficaries.
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