Paris Saint-Germain and Napoli are both in high spirits having picked up morale-boosting Group C wins last time out.
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Borussia Dortmund and Atlético Madrid are level on six points at the top of Group A ahead of their meeting in Germany
PSV Eindhoven and Tottenham are without a point in Group B and cannot afford a third defeat as they meet.
Galatasaray will be looking for a repeat of their previous display in Istanbul against Schalke, who are unbeaten in Group D.
Club Brugge and Monaco are both without a point in Group A, and know now is the time to make an impact.
Thierry Henry, 41, has taken his first job as a head coach at Monaco, the club where he began his playing career.
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